从 2018 年引进单细胞实验平台，到 2019 年烈冰助力第一篇单细胞文章，

在单细胞领域烈冰助力用户发表单细胞文献 100+ 篇 (不完全统计)，总 IF>1400+!

包含Nature、Cancer cell、Immunity、Circulation、Journal of Infection、Cell Discovery、Nature Neuroscience、GUT、Science Immunology、Nature Cell Biology、Nature Plants等生物领域国际顶尖学术期刊，

已发表文章研究领域涵盖免疫、肿瘤、脑科学、牙科、骨科、疫苗研究、植物等各个领域。

2023 年，截止到今天，助力用户发表单细胞文献 36篇，平均IF超15!

2023
取得佳绩

免疫研究领域

1、A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency

期刊：Science Immunology

研究方向：免疫缺陷

2、Tumor-intrinsic YTHDF1 drives immune evasion and resistance to immune checkpoint inhibitors via promoting MHC-I degradation

期刊：Nature Communications

研究方向：肿瘤免疫逃逸

解读链接：https://mp.weixin.qq.com/s/kgrIrpWkCmV5V02ZKigq3A

3、Systemic immune dysregulation in severe tuberculosis patients revealed by a single-cell transcriptome atlas

期刊：Journal of Infection

研究方向：结核病免疫失调

解读链接：https://mp.weixin.qq.com/s/3igJ9rBCmFfazqVxPbCpCw

4、Schwann cells regulate tumor cells and cancer-associated fibroblasts in the pancreatic ductal adenocarcinoma microenvironment

期刊：Nature Communications

研究方向：胰腺癌免疫微环境

解读链接：https://mp.weixin.qq.com/s/99RdAfqjmig7W55UPROmmA

5、Targeting neoadjuvant chemotherapy-induced metabolic reprogramming in pancreatic cancer promotes anti-tumor immunity and chemo-response

期刊：Cell Reports Medicine

研究方向：免疫治疗

6、Targeting IRG1 reverses the immunosuppressive function of tumor-associated macrophages and enhances cancer immunotherapy

期刊：Science Advances

研究方向：免疫治疗

解读链接：https://mp.weixin.qq.com/s/o4CMJ5Wlelb3i4YKmJo_hA

以上为烈冰生物2023最新助力在免疫研究领域的高分单细胞测序文献，更多助力文献可关注公众号或联系驻地销售获取更详细文献列表~

肿瘤研究领域

1、Single-Cell Landscape Highlights Heterogenous Microenvironment, Novel Immune Reaction Patterns,Potential Biomarkers and Unique Therapeutic Strategies of Cervical Squamous Carcinoma, Human Papillomavirus-Associated(HPVA) and Non-HPVA Adenocarcinoma

期刊：Advanced Science

研究方向：宫颈鳞癌

2、NNMT enriches for AQP5+ cancer stem cells to drive malignant progression in early gastric cardia adenocarcinoma

期刊：GUT

研究方向：胃贲门腺癌

3、Single-cell and spatial dissection of precancerous lesions underlying the initiation

process of oral squamous cell carcinoma

期刊：Cell Discovery

研究方向：口腔鳞癌

4、Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer

期刊：Cancer Cell

研究方向：前列腺癌

解读链接：https://mp.weixin.qq.com/s/JVBKNLuOCRX35yVEl2KHyA

5、TWEAK Signaling-Induced ID1 Expression Drives Malignant Transformation of Hepatic Progenitor Cells During Hepatocarcinogenesis

期刊：Advanced Science

研究方向：肝癌

6、Immunosuppressive CD10+ALPL+ neutrophils promote resistance to anti-PD-1therapy in HCC by mediating irreversible exhaustion of T cells

期刊：Journal of Hepatology

研究方向：肝癌

解读链接：https://mp.weixin.qq.com/s/bRJnFxZgJ7saRGQqQNn-UA

7、ECSIT Is a Critical Factor for Controlling Intestinal Homeostasis and Tumorigenesis through Regulating the Translation of YAP Protein

期刊：Advanced Science

研究方向：肠道肿瘤

以上为烈冰生物2023最新助力在肿瘤研究领域的高分单细胞测序文献，更多助力文献可关注公众号或联系驻地销售获取更详细文献列表~

神经研究领域

1、Integrating spatial and single-nucleus transcriptomic data elucidates microglial-specific responses in female cynomolgus macaques with depressive-like behaviors

期刊：Nature Neuroscience

研究方向：抑郁症

解读链接：https://mp.weixin.qq.com/s/BdUfrluolINoQ2ayD5BFZQ

2、Single-nucleus profiling of adult mice sub-ventricular zone after blast-related traumatic brain injury

期刊：Scientific Data

研究方向：脑损伤

3、Novel CH25H+ and OASL+ microglia subclusters play distinct roles in cerebral ischemic stroke

期刊：Journal of Neuroinflammation

研究方向：脑缺血性卒中

4、Single-nucleus transcriptomic mapping of blast-induced traumatic brain injury in mice hippocampus

期刊：Scientific Data

研究方向：脑损伤

以上为烈冰生物2023最新助力在神经研究领域的高分单细胞测序文献，更多助力文献可关注公众号或联系驻地销售获取更详细文献列表~